Liverpool midfielder Adam Lallana will miss the match with a thigh injury, captain Jordan Henderson is still not fit to return from a foot problem which has sidelined him since early February and Daniel Sturridge's rehabilitation is continuing.
Liverpool, now sitting in fourth position in the league, take on Everton this Saturday in a Merseyside derby that Lallana certainly would have started if fit.
Lallana took a kick to the leg during England's World Cup qualification victory over Lithuania at Wembley on Sunday, and despite playing the full 90 minutes has subsequently succumbed to the knock.
Liverpool's Adam Lallana will miss up to four weeks including Saturday's Merseyside derby after picking up a thigh injury while on worldwide duty.
There is no timescale on Lallana's recovery, but he could potentially miss five games. "We both share players".
Alejandro Moreno tells us where Liverpool goes from here after Adam Lallana will be on the shelf for a month with a thigh injury.
Plus, this is unwelcome news just four days before the Merseyside Derby against Everton on Saturday at Anfield.
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It also says that the outlets should not be directly accessible from national and state highway and situated within a distance of 500 metres.
He is joint-sixth for assists in the Premier League this season after setting up seven of Liverpool's goals.
With Lovren, Klavan and Joel Matip at his disposal, his side have been left to field the likes of Lucas Leiva at the back when they've come up short through injury this season.
"I couldn't be less relaxed about this but it's not about blaming Gareth Southgate", Klopp said, as quoted by The Independent.
With England team-mate Nathaniel Clyne taking part in the training session, fans felt further assured that their worst fears had been realised. His creativity has made him crucial in linking Liverpool's midfield and attack, and has translated into a lot of chances created and goals scored.
This is the second time this season that Lallana has suffered an injury coming off an worldwide break.
Lallana has been a key player for Liverpool this season, as they look to secure a top four finish.
The Exploding Heads preview the Merseyside Derby, but Ian Fiveankles debates whether this is actually a derby.