This time, Adam Lallana returned from England duty with a thigh injury that has ruled him out for up to 4 weeks.
Lallana is expected to miss up to a month because of the injury, and his absence will be a major blow to the Liverpool attack.
Footage emerged on Tuesday of Lallana rubbing his left thigh in discomfort after the first half of the 2-0 win against Lithuania on Sunday, but he saw out the full 90 minutes.
Jurgen Klopp has spoken out about the injury suffered by Adam Lallana on global duty last week, but says he does not blame England manager Gareth Southgate.
Sources have told ESPN FC that Klopp has spoken to Gareth Southgate, which the England boss commonly does with club managers, following Lallana's diagnosis.
Lallana has scored seven goals and has made seven assists in 27 games in the 2016-17 Premier League season.
Klopp has been extremely careful with Liverpool's youngest-ever goal scorer, but 17-year-old Ben Woodburn can also feature as a central midfielder and could be an option if Liverpool are down to the bare bones.
Merkel's Deputy Bouffier: Erdogan Not Wanted in Germany
He said Berlin should not rely on local and state governments to make decisions about visits by Turkish politicians as it has up to now.
With Liverpool battling to qualify for the Champions League via a top four finish, Klopp knows his team can ill-afford to be without Lallana for long.
Such a lay-off would see the former Southampton midfielder miss five of Liverpool's remaining nine Premier League fixtures, beginning with Saturday's derby against Everton at Anfield.
'I really think we could handle these situations better if we work together. It's not about blaming Gareth Southgate.
Which means the Reds' weekend clash with local rivals Everton holds all the more weight.
He will play no part in tomorrow's Merseyside derby. Making that tactical switch would, of course, hand Divock Origi a start as one of Liverpool's three forwards.
Henderson has been excellent in the number six spot the entire season, but Lallana's injury may force Liverpool's captain to play further forward in a position he has excelled throughout his Liverpool career.